Scientists of the Novosibirsk State Agrarian University (NSAU) have found a way to create a new generation of biological products, "piercing" the immunity of insect pests.
The work was done on the basis of previously obtained data on the nature of the resistance of insects to diseases, said Ekaterina Grizanova, leading researcher at the Laboratory for Plant Biological Protection and Biotechnology of NSAU.
«Pests insects become resistant to biological products due to increased immunity, several immune reactions. If we add immunosuppressants (a class of drugs of artificial suppression of immunity) to the drug, we will improve it, it will become more effective. Or, based on our research, you can create a new generation of drugs, for example, based on RNA interference (a mechanism for controlling gene activity) or transgenic plants", Said Grisanova.
According to her, today she works in the direction of RNA interference. This method allows you to control the activity of insect genes and suppress their resistance to biological products. The interlocutor of the agency claims that it is possible to change the genome of microbes, thereby increasing the infectivity of insects.
Previously, NSAU scientists found out due to which insect pests become resistant to biological products. "We have selected several generations of insects for resistance to bacteria. Each generation was infected, the strongest were taken, and selected again. And we began to compare the strongest with the sensitive. Thus, we discovered several key mechanisms of insect resistance.“, Said Grisanova.
According to her, the laboratory staff found out that insect immune system, regeneration, intestinal recovery after infection and other mechanisms are responsible for resistance, in particular.
For this study, Grisanova was awarded the Presidential Prize in Science and Innovation for 2018. For 10 years of the existence of the prize, the field of agriculture was first noted. The girl herself became the youngest winner at the end of the year.
A source: https://agronews.com